Janet won't have any communication with Tommy since the death of their son, Connor. After months of using a middle man, she finally gives him a sit down to discuss their future. Meanwhile, Sheila asks Tommy to discuss with Damian what she found in one of his drawers. It could lead to a uncomfortable situation with someone at Damian's school. Also, the boys of 62 Truck make a personal decision that could drive each of them insane.

The boys from 62 Truck decide to go out after discovering their private lives aren, 't quite what they used to be. While at the Lotus, Franco becomes intrigued with a beautiful older woman who is checking him out from across the bar. Chief Reilly comes to realize that paying for Jeanie, 's care may be a bigger burden on himself than he thought and turns to a friend that, 's not doing well himself for help and Sean continues to mull over whether or not to tell Tommy about him and Maggie. Also, Tommy, 's dad is celebrating his 83rd birthday with family and friends when Tommy makes a shocking discovery that will rip his family apart.

Tommy attempts to end the relationship of Damian and Mrs. Turbody, but it may lead him to a situation that is equally as problematic for him. Franco starts a relationship with Alicia, the older woman he met at the Lotus while on guys night out, and she begins to become more involved with his life. Plus, some of the other boys of 62 Truck are having a bit of their own problems, including Sean continuing to keep his relationship with Maggie a secret from Tommy and Lou's drinking.

The boys of 62 Truck are on their way to a cardiac call in Harlem when they spot a school bus that has tipped over on it's side. They decide to help and sent another Truck to Harlem and are lambasted in the media by Rev. Al Sharpton for it. Franco's relationship is getting more serious with Alicia. He begins to think there is more Alicia's attraction to him than just him. Sean finally tells Tommy about him and Maggie and Sheila has a proposal for Tommy that would shake the family around again.

episode 5 of rescue me season 3 kicks off with angie the ex girfriend of johney is looked by tommy to make johny feel jealous.Tommy and Janet's divorce begins to seem real as the guys help clear the apartment of Janet's things and Tommy has to face Janet's new relationship face-to-face. On the other hand, Johnny's ex-wife reappears and makes an interesting deal with Tommy that will prove to shake things up among the Gavin family.

Sean begins to sleepwalk when he accidentally takes some of Tommy's sleeping pills instead of the painkillers he was after. Meanwhile, Angie finally agrees to go out on a fictional date with Tommy in hopes of making Janet and Johnny jealous. Also, Lou has a heart to heart with his Uncle Red that helps him get through an incident during a fire that almost cost him and another one in his house their lives.

Tommy and Angie decide to show off their fake relationship right in front of Janet and Johnny at a NYPD reception and banquet, but Sheila sees it and is furious at Tommy and Angie together. Sean thinks about getting back with Maggie after her new found interest in his manly side and Mike picks up a woman he is attracted to much to Chris' dislike. Franco knows about Chief Reilly's other job and gets Tommy to go over to it to hassle him a bit.

Tommy has a stand-off with a wise-ass NYPD hockey player that leads to another one of his emotional breakdowns in the locker room. Meanwhile, Lou finally gets his life’s second wind and decides to get off his dead ass and not let what happened to him and Candi destroy his life. Also Franco finds himself with a woman who might seem like someone with whom he could have a serious relationship with. Tommy and Angie, Sean and Maggie, Probie and Chris, Jerry and Rose, and Teddy and Ellie all come to the point where they have to make important decisions about where their relationships are going.

Tommy is beginning to worry that the one thing in his life that appears to be stable, his crew, may be starting to break apart and he is concerned how it will effect his own career. Sheila makes a proposition to Tommy when he confides in her. Franco's new girlfriend, Natalie, finally shows him why she is apprehensive about him coming to her place. Meanwhile, the Chief gets some advise about his life and how he may want to deal with his wife. Also, Probie comes clean to the crew about him and Chris. Johnny begins to reach out towards Tommy, but with news that he believes Tommy won't want to hear.

Tommy and Johnny have it out again when Tommy meets with Janet about how they are going to deal with their situation and what they are going to tell the rest of the family. Also Tommy continues to be a Stacks bedside while he fights for his life. Franco makes an effort to become better friends with Natalie's brother, Richard, and it takes their relationship to a new place. Teddy and Ellie's conjugal visits begin to be a let down to Ellie because of where they are and she starts to make changes to increase the mood. Meanwhile, Mike finally puts in his transfer forms to Chief Perolli.

Tommy's dad decides to take off while Tommy is gone after they have an argument about their living situation and Tommy has a problem with Lou when he brings home someone that Tommy in uncomfortable with. Sean and Maggie decide to have a Catholic wedding and go to see the priest. It doesn't turn out to quite the way that Sean had imagined it would. Two people in Tommy's life are struck down in what may be the final straw for Tommy.

Yet another family tragedy strikes at the Gavins, the outcome of which may bring Tommy and Janet close again as they try to deal with the outcome and Chief Reilly uncharacteristically doesn't show up for work or call. The crew begins to worry and goes to check on him. Maggie and Sean make a spontaneous decision about their future together and Mike turns to a spiritual figure to seek advice about his sexuality.

Tommy and Janet decide on a course of action as it pertains to her pregnancy and after the child is born, but is reluctant to tell her about the plans he was making with Sheila. Franco becomes upset with himself about how has been handling his daughter and goes to see her. Meanwhile, many of the crew are planning how they are going to leave 62 Truck.